The 2022 Indiana CTSI Retreat, hosted by the University of Notre Dame, was held virtually on Wednesday, March 30, 2022. The retreat theme was “Modern Approaches to Drug Discovery" and featured speakers from Indiana CTSI partner institutions, Eli Lilly and Company, the University of Michigan, as well as Research Blitz presentations over lunch.
Continue below to see the day's agenda, speakers list, and watch the presentation recordings.
Download the Digital Retreat Booklet
Agenda:
9:00-9:10 a.m.
Opening Remarks
Robert J. Bernhard, Vice President for Research and Professor of Aerospace and Mechanical Engineering, University of Notre Dame
9:10-9:20 a.m.
Overview of Indiana CTSI
Sarah Wiehe and Sharon Moe, co-directors of the Indiana CTSI
9:20-10:00 a.m.
Idea2Data: Expediting Drug Discovery through Automation and Computation
Christos A. Nicolaou, Senior Research Advisor, Discovery Chemistry and Research Technologies, Eli Lilly and Company
10:00-10:50 a.m.
Strategies for Small-Molecule Inhibition of Transcription Factors in Cancer
Samy Meroueh, professor of biochemistry & molecular biology, Indiana University School of Medicine
10:50-11:00 a.m.
Break
11:00-11:50 a.m.
Novel Chemotypes of Kinase Inhibitors for the Potential Treatment of Recurrent Cancers
Herman Sintin, Drug Discovery Professor of Chemistry, Purdue University
11:50 a.m.-12:00 p.m.
Grab your lunch and join one of the Research Blitz Sessions
12:00 a.m.-12:50 p.m.
Research Blitz Sessions
Session 1: Chronic Disorders and Injuries
Tyler Nguyen
“Real-time assessments of caspase-1 mediated inflammation after repetitive traumatic brain injury and its role in long-term pain”
Nicole Weaver
“The role of gldc in the embryonic kidney”
Kaylee Cloghessy
“Assessing Genetic Mechanisms Underlying the Regenerative Response to Traumatic Brain Injury in the Adult Zebrafish Telencephalon using scRNA-Seq”
Gowthami Mahendran
“Unraveling the pathways affected in Miller-Dieker Syndrome through gene expression analysis”
Session 2: Parasitic and Bacterial Infections/Cancer
Joshua Shrout
“Appreciating InterSpecies Bacterial Interactions in Prosthetic Joint Infection”
Michelle Huang
“Integrating DNA Diagnostics and Population Genomics to Benefit Human Health: A Test Case Using the Causative Agent of Chagas Disease (Trypanosoma cruzi) and its Insect Vector (Triatominae)”
Alicia Wei
“Smart Breast Clip: A Wireless Implant for Continuous Molecular Sensing of Breast Masses”
Sunghoon Rho
“Optically-enhanced wireless breast lesion localization device for use during lumpectomy”
Xin Lu
“Targeting Basal-Like Prostate Cancer with Cadherin 3 Antibody-Drug Conjugate (ADC) as single agent and in combination with immunotherapy”
12:50-1:40 p.m.
Modulators of Proteostasis Pathways and Protein Folding
Juan Del Valle, William K. Warren Family Associate Professor, department of chemistry and biochemistry, University of Notre Dame
1:40-2:15 p.m.
Support Structures for Translational Drug Discovery
Andrew Dahlem, chief of clinical pharmacology and senior research professor of medicine, IU School of Medicine
Richard Taylor, director of the Molecular Therapeutics Program for the Indiana CTSI and professor of chemistry and biochemistry, University of Notre Dame
2:15-2:25 p.m.
Break
2:25-3:25 p.m.
My Journey in Academia Drug Discovery Research: From Targeting Protein-Protein Interactions to Induced Protein Degradation
Shaomeng Wang, the Warner-Lambert/Parke-Davis Professor in Medicine and Professor of Medicine, Pharmacology and Medicinal Chemistry, University of Michigan Medical School
3:25-3:40 p.m.
Closing Remarks
Brian Blagg, Charles Huisking Professor of Chemistry and Biochemistry and Director of the Warren Family Research Center for Drug Discovery and Development, University of Notre Dame
Melanie DeFord, Assistant Vice President for Research and Deputy Director of the Indiana CTSI, University of Notre Dame